Astrogliosis and sexually dimorphic neurodegeneration and microgliosis in the olfactory bulb in Parkinson's disease.

ABSTRACT: Hyposmia is prodromal, and male sex is a risk marker for an enhanced likelihood ratio of Parkinson's disease. The literature regarding olfactory bulb volume reduction is controversial, although the olfactory bulb has been largely reported as an early and preferential site for α-synucleinopathy. These pathological deposits have been correlated with neural loss in Nissl-stained material. However, microgliosis has rarely been studied, and astrogliosis has been virtually neglected. In the present report, α-synucleinopathy (α-synuclein), neurodegeneration (Neu-N), astrogliosis (GFAP), and microgliosis (Iba-1) were quantified, using specific markers and stereological methods. Disease, sex, age, disease duration, and post-mortem interval were considered variables for statistical analysis. No volu

SUBMITTER: Flores-Cuadrado A 

PROVIDER: S-EPMC7820595 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature