Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect.

ABSTRACT: Methods to repair bone defects arising from trauma, resection, or disease, continue to be sought after. Cyclic mechanical loading is well established to influence bone (re)modelling activity, in which bone formation and resorption are correlated to micro-scale strain. Based on this, the application of mechanical stimulation across a bone defect could improve healing. However, if ignoring the mechanical integrity of defected bone, loading regimes have a high potential to either cause damage or be ineffective. This study explores real-time finite element (rtFE) methods that use three-dimensional structural analyses from micro-computed tomography images to estimate effective peak cyclic loads in a subject-specific and time-dependent manner. It demonstrates the concept in a cyclically loaded m

SUBMITTER: Malhotra A 

PROVIDER: S-EPMC7820598 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature