Comparison of calcium-channel blockers for long-term clinical outcomes in patients with vasospastic angina.

ABSTRACT:

Background/aims

Calcium channel blockers (CCBs) are the most widely prescribed medication for patients with vasospastic angina (VA). However, few studies have compared the prognosis of VA patients who are prescribed different CCBs.

Methods

We enrolled 2,960 patients who received provocation test prospectively in 11 university hospitals in Korea. We divided 1,586 patients received four major CCBs into two groups: a first generation CCB (diltiazem and nifedipine) group and a second generation CCB (amlodipine and benidipine) group. Primary outcome was time to events of composite of death from any cause, acute coronary syndrome (ACS) and symptomatic arrhythmia during 3-year follow-up. We also compared the effect of each CCB on the control of angina symptoms.

Results

There

SUBMITTER: Kim SE 

PROVIDER: S-EPMC7820640 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature