Mild pericyte deficiency is associated with aberrant brain microvascular flow in aged PDGFRβ^+/- mice.

ABSTRACT: The receptor tyrosine kinase PDGFRβ is essential for pericyte migration to the endothelium. In mice lacking one allele of PDGFRβ (PDGFRβ^+/-), previous reports have described an age-dependent loss of pericytes in the brain, leading to cerebrovascular dysfunction and subsequent neurodegeneration reminiscent of that seen in Alzheimer's disease and vascular dementia. We examined 12-20-month-old PDGFRβ^+/- mice to better understand how pericyte loss affects brain microvascular structure and perfusion in vivo. We observed a mild reduction of cortical pericyte number in PDGFRβ^+/- mice (27% fewer cell bodies) compared to controls, but no decrease in pericyte coverage of the endothelium. This mild degree of pericyte loss caused no discernable change in cortical micro

SUBMITTER: Watson AN 

PROVIDER: S-EPMC7820684 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature