Mild metabolic stress is sufficient to disturb the formation of pyramidal cell ensembles during gamma oscillations.

ABSTRACT: Disturbances of cognitive functions occur rapidly during acute metabolic stress. However, the underlying mechanisms are not fully understood. Cortical gamma oscillations (30-100 Hz) emerging from precise synaptic transmission between excitatory principal neurons and inhibitory interneurons, such as fast-spiking GABAergic basket cells, are associated with higher brain functions, like sensory perception, selective attention and memory formation. We investigated the alterations of cholinergic gamma oscillations at the level of neuronal ensembles in the CA3 region of rat hippocampal slice cultures. We combined electrophysiology, calcium imaging (CamKII.GCaMP6f) and mild metabolic stress that was induced by rotenone, a lipophilic and highly selective inhibitor of complex I in the respiratory ch

SUBMITTER: Elzoheiry S 

PROVIDER: S-EPMC7820691 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature