The Clinical Characteristics of Other HLA-B Types in Chinese Ankylosing Spondylitis Patients.

ABSTRACT: HLA-B27 has an established relationship with the development of ankylosing spondylitis (AS). After reviewing the HLA-B genotype from 407 Chinese subjects (318 patients and 89 sex-matched controls), we found that 252 patients and 32 controls were HLA-B27(+) and that HLA-B^*27:04 was the dominant HLA-B27 subtype (N = 224). In all participants, HLA^*27:04 homozygous were only detected in two patients. In the HLA-B27(+) group, HLA-B40 was observed in 51 cases and one control (p < 0.05, OR = 7.87, 95% CI 1.05-59.0); of these, the most genotype was HLA-B^*27:04/B^*40:01(N = 38). Two hundred thirty-nine patients' clinical information was recorded. Cases with HLA-B27/B46 had more peripheral joint involvement (OR = 3.95, 95% CI 1.77-8.79)

SUBMITTER: Wu X 

PROVIDER: S-EPMC7820707 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature