Distinguishing pedigree relationships via multi-way identity by descent sharing and sex-specific genetic maps.

ABSTRACT: The proportion of samples with one or more close relatives in a genetic dataset increases rapidly with sample size, necessitating relatedness modeling and enabling pedigree-based analyses. Despite this, relatives are generally unreported and current inference methods typically detect only the degree of relatedness of sample pairs and not pedigree relationships. We developed CREST, an accurate and fast method that identifies the pedigree relationships of close relatives. CREST utilizes identity by descent (IBD) segments shared between a pair of samples and their mutual relatives, leveraging the fact that sharing rates among these individuals differ across pedigree configurations. Furthermore, CREST exploits the profound differences in sex-specific genetic maps to classify pairs as maternall

SUBMITTER: Qiao Y 

PROVIDER: S-EPMC7820736 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature