Depiction of Vaginal Microbiota in Women With High-Risk Human Papillomavirus Infection.

ABSTRACT: Persistent infection with the carcinogenic human papillomavirus (HPV) is a prerequisite for the progression of cervical lesions and cancer. A growing body of research has focused on the functional role of the vaginal microbiota in the persistence of HPV infection. Understanding the microbial composition and structure in women with high-risk (hr)-HPV infection may help reveal associations between the vaginal microbiota and HPV infection, and identify potential biomarkers. Our study investigated the vaginal microbial community in women with and without hr-HPV infection, by using 16s rRNA gene sequencing. We found that microbial perturbations occurred in the early phase of hr-HPV infection. Lactobacillus and Sporolactobacillus were decreased, while bacteria related to bac

SUBMITTER: Wei ZT 

PROVIDER: S-EPMC7820762 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature