Hydroxyapatite Particle Density Regulates Osteoblastic Differentiation Through β-Catenin Translocation.

ABSTRACT: Substrate surface characteristics such as roughness, wettability and particle density are well-known contributors of a substrate's overall osteogenic potential. These characteristics are known to regulate cell mechanics as well as induce changes in cell stiffness, cell adhesions, and cytoskeletal structure. Pro-osteogenic particles, such as hydroxyapatite, are often incorporated into a substrate to enhance the substrates osteogenic potential. However, it is unknown which substrate characteristic is the key regulator of osteogenesis. This is partly due to the lack of understanding of how these substrate surface characteristics are transduced by cells. In this study substrates composed of polycaprolactone (PCL) and carbonated hydroxyapatite particles (HAp) were synthesized. HAp concentration

SUBMITTER: Juhl OJ 

PROVIDER: S-EPMC7820766 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature