Destabilizing Different Strengths of Fear Memories Requires Different Degrees of Prediction Error During Retrieval.

ABSTRACT: Reactivation of consolidated memories can induce a labile period, in which these reactivated memories might be susceptible to change and need reconsolidation. Prediction error (PE) has been recognized as a necessary boundary condition for memory destabilization. Moreover, memory strength is also widely accepted as an essential boundary condition to destabilize fear memory. This study investigated whether different strengths of conditioned fear memories require different degrees of PE during memory reactivation in order for the memories to become destabilized. Here, we assessed the fear-potentiated startle and skin conductance response, using the post-retrieval extinction procedure. A violation of expectancy (PE) was induced during retrieval to reactivate enhanced (unpredictable-shock) or o

SUBMITTER: Chen W 

PROVIDER: S-EPMC7820768 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature