Genomic Epidemiology of Antimalarial Drug Resistance in Plasmodium falciparum in Southern China.

ABSTRACT: Emerging artemisinin resistance in Southeast Asia poses a significant risk to malaria control and eradication goals, including China's plan to eliminate malaria nationwide by 2020. Plasmodium falciparum was endemic in China, especially in Southern China. Parasites from this region have shown decreased susceptibility to artemisinin and delayed parasite clearance after artemisinin treatment. Understanding the genetic basis of artemisinin resistance and identifying specific genetic loci associated with this phenotype is crucial for surveillance and containment of resistance. In this study, parasites were collected from clinical patients from Yunnan province and Hainan island. The parasites were genotyped using a P. falciparum-specific single nucleotide polymorphism (SNP) microar

SUBMITTER: Huang F 

PROVIDER: S-EPMC7820777 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature