Persistently higher serum sCD40L levels are associated with outcome in septic patients.

ABSTRACT:

Background

Soluble CD40 ligand (sCD40L) exhibits proinflammatory and procoagulant effects. Recent data indicated that sCD40L plays a significant role in septic patients. The aim of the present study was to determine sCD40L changes in surgical patients without sepsis (SWS) and surgical sepsis patients (SS) during the first 3 days after intensive care unit (ICU) admission and to observe the association between sCD40L and mortality.

Methods

Time changes in sCD40L levels were assessed for 3 days after ICU admission in 49 patients with SS and compared with those in 19 SWS patients. Serum sCD40L concentration was detected by ELISA. Survival at 28 days served as the endpoint.

Results

SS had significantly higher sCD40L levels than SWS and control patients. We observed an asso

SUBMITTER: Liang Y 

PROVIDER: S-EPMC7820820 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature