Computational annotation of miRNA transcription start sites.

ABSTRACT:

Motivation

MicroRNAs (miRNAs) are small noncoding RNAs that play important roles in gene regulation and phenotype development. The identification of miRNA transcription start sites (TSSs) is critical to understand the functional roles of miRNA genes and their transcriptional regulation. Unlike protein-coding genes, miRNA TSSs are not directly detectable from conventional RNA-Seq experiments due to miRNA-specific process of biogenesis. In the past decade, large-scale genome-wide TSS-Seq and transcription activation marker profiling data have become available, based on which, many computational methods have been developed. These methods have greatly advanced genome-wide miRNA TSS annotation.

Results

In this study, we summarized recent computational methods and their results on

SUBMITTER: Wang S 

PROVIDER: S-EPMC7820843 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature