Ontology highlight
ABSTRACT:
SUBMITTER: Ioannou N
PROVIDER: S-EPMC7820876 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Ioannou Nikolaos N Hagner Patrick R PR Stokes Matt M Gandhi Anita K AK Apollonio Benedetta B Fanous Mariam M Papazoglou Despoina D Sutton Lesley-Ann LA Rosenquist Richard R Amini Rose-Marie RM Chiu Hsiling H Lopez-Girona Antonia A Janardhanan Preethi P Awan Farrukh T FT Jones Jeffrey J Kay Neil E NE Shanafelt Tait D TD Tallman Martin S MS Stamatopoulos Kostas K Patten Piers E M PEM Vardi Anna A Ramsay Alan G AG
Blood 20210101 2
Cancer treatment has been transformed by checkpoint blockade therapies, with the highest anti-tumor activity of anti-programmed death 1 (PD-1) antibody therapy seen in Hodgkin lymphoma. Disappointingly, response rates have been low in the non-Hodgkin lymphomas, with no activity seen in relapsed/refractory chronic lymphocytic leukemia (CLL) with PD-1 blockade. Thus, identifying more powerful combination therapy is required for these patients. Here, we preclinically demonstrate enhanced anti-CLL a ...[more]