Transcriptional Dynamics of Hepatic Sinusoid-Associated Cells After Liver Injury.

ABSTRACT:

Background and aims

Hepatic sinusoidal cells are known actors in the fibrogenic response to injury. Activated hepatic stellate cells (HSCs), liver sinusoidal endothelial cells, and Kupffer cells are responsible for sinusoidal capillarization and perisinusoidal matrix deposition, impairing vascular exchange and heightening the risk of advanced fibrosis. While the overall pathogenesis is well understood, functional relations between cellular transitions during fibrogenesis are only beginning to be resolved. At single-cell resolution, we here explored the heterogeneity of individual cell types and dissected their transitions and crosstalk during fibrogenesis.

Approach and results

We applied single-cell transcriptomics to map the heterogeneity of sinusoid-associated cells in hea

SUBMITTER: Terkelsen MK 

PROVIDER: S-EPMC7820956 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature