Dynamics of microbial competition, commensalism, and cooperation and its implications for coculture and microbiome engineering.

ABSTRACT: Microbial consortium is a complex adaptive system with higher-order dynamic characteristics that are not present by individual members. To accurately predict the social interactions, we formulate a set of unstructured kinetic models to quantitatively capture the dynamic interactions of multiple microbial species. By introducing an interaction coefficient, we analytically derived the steady-state solutions for the interacting species and the substrate-depleting profile in the chemostat. We analyzed the stability of the possible coexisting states defined by competition, parasitism, amensalism, commensalism, and cooperation. Our model predicts that only parasitism, commensalism, and cooperation could lead to stable coexisting states. We also determined the optimal social interaction criteria

SUBMITTER: Xu P 

PROVIDER: S-EPMC7821011 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature