Polymorphisms of the μ-opioid receptor gene influence cerebral pain processing in fibromyalgia.

ABSTRACT:

Background

Dysregulation of the μ-opioid receptor has been reported in fibromyalgia (FM) and was linked to pain severity. Here, we investigated the effect of the functional genetic polymorphism of the μ-opioid receptor gene (OPRM1) (rs1799971) on symptom severity, pain sensitivity and cerebral pain processing in FM subjects and healthy controls (HC).

Methods

Symptom severity and pressure pain sensitivity was assessed in FM subjects (n = 70) and HC (n = 35). Cerebral pain-related activation was assessed by functional magnetic resonance imaging during individually calibrated painful pressure stimuli.

Results

Fibromyalgia subjects were more pain sensitive but no significant differences in pain sensitivity or pain ratings were observed between OPRM1 genotypes. A significa

SUBMITTER: Ellerbrock I 

PROVIDER: S-EPMC7821103 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature