Development of a model to predict vestibular schwannoma growth: An opportunity to introduce new wait and scan strategies.

ABSTRACT:

Objectives

To develop a prediction model to predict vestibular schwannoma (VS) growth for patients in a wait and scan (W&S) strategy.

Design

Retrospective cohort study.

Setting

Tertiary hospital (Radboud university medical center, Nijmegen, the Netherlands).

Participants

Patients with unilateral VS, entering a W&S strategy and at least one follow-up MRI available. Data on demographics, symptoms, audiometry and MRI characteristics at time of diagnosis were collected from medical records.

Main outcome measures

Following multiple imputation, a multivariable Cox regression model was used to select variables, using VS growth (≥2 mm) as outcome. Decision curve analyses (DCA) were performed to compare the model to the current strategy.

Results

Of 1217 an

SUBMITTER: Hentschel MA 

PROVIDER: S-EPMC7821120 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature