Combining chemical exchange saturation transfer and ¹ H magnetic resonance spectroscopy for simultaneous determination of metabolite concentrations and effects of magnetization exchange.

ABSTRACT:

Purpose

A new sequence combining chemical-exchange saturation-transfer (CEST) with traditional MRS is used to simultaneously determine metabolite content and effects of magnetization exchange.

Methods

A CEST saturation block consisting of a train of RF-pulses is placed before a metabolite-cycled semi-LASER single-voxel spectroscopy sequence. The saturation parameters are adjustable to allow optimization of the saturation for a specific target. Data were collected in brain from 20 subjects in experiments with different B₁ -settings (0.4-2.0 µT) on a 3T MR scanner. CEST Z-spectra were calculated from water intensities and fitted with a multi-pool Lorentzian model. Interrelated metabolite spectra were fitted in fitting tool for arrays of interrelated datasets (FiTAID

SUBMITTER: Hoefemann M 

PROVIDER: S-EPMC7821128 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature