CD73 contributes to anti-inflammatory properties of afferent lymphatic endothelial cells in humans and mice.

ABSTRACT: CD73 is an important ectoenzyme responsible for the production of extracellular adenosine. It is involved in regulating inflammatory responses and cell migration and is overexpressed in various cancers. The functions of CD73 in blood endothelial cells are understood in detail, but its role on afferent lymphatics remains unknown. Moreover, anti-CD73 antibodies are now used in multiple clinical cancer trials, but their effects on different endothelial cell types have not been studied. This study reveals that a previously unknown role of CD73 on afferent lymphatics is to dampen immune responses. Knocking it out or suppressing it by siRNA leads to the upregulation of inflammation-associated genes on lymphatic endothelial cells and a more pro-inflammatory phenotype of interacting dendritic cell

SUBMITTER: Eichin D 

PROVIDER: S-EPMC7821194 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature