Increased risk of incident dementia following use of anticholinergic agents: A systematic literature review and meta-analysis.

ABSTRACT:

Background/rationale

Long-term treatment with anticholinergic agents may increase the risk of cognitive impairment or dementia. This systematic literature review and meta-analysis aimed to assess the impact of ≥3 months of exposure to anticholinergics as a class on the risk of dementia, mild cognitive impairment, and change in cognitive function. The impact of anticholinergic agents specifically used to treat overactive bladder was also evaluated.

Materials and methods

A systematic literature review was conducted to identify English language articles evaluating the impact of anticholinergic use for ≥3 months on dementia or cognitive function in adult patients. Databases searched included PubMed, Embase, and the Cochrane Library. Meta-analyses were conducted using random-effe

SUBMITTER: Dmochowski RR 

PROVIDER: S-EPMC7821204 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature