Possible association between early formula and reduced risk of cow's milk allergy: The Japan Environment and Children's Study.

ABSTRACT:

Background

Despite evidence for the protective effects of early regular exposure to peanut and egg proteins against allergies, the optimal timing of cow's milk (CM) protein exposure is unknown.

Objective

We aimed to determine when during the first year of life CM-based formula consumption becomes associated with lower CM allergy (CMA) risk.

Methods

We used the data set of the Japan Environment and Children's Study (JECS), a nationwide birth cohort involving over 100 000 mother-child pairs. CMA was defined as an allergic reaction to a CM product in an individual not consuming CM products at the time of evaluation, combined with physician-diagnosed food allergy. For each exposure, we identified when formula milk was commenced, and its consumption status during 0-3, 3-6

SUBMITTER: Tezuka J 

PROVIDER: S-EPMC7821216 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature