Δ⁹ -Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo.

ABSTRACT: Δ⁹ -Tetrahydrocannabinol (THC), the main bioactive compound found in the plant Cannabis sativa, exerts its effects by activating cannabinoid receptors present in many neural cells. Cannabinoid receptors are also physiologically engaged by endogenous cannabinoid compounds, the so-called endocannabinoids. Specifically, the endocannabinoid 2-arachidonoylglycerol has been highlighted as an important modulator of oligodendrocyte (OL) development at embryonic stages and in animal models of demyelination. However, the potential impact of THC exposure on OL lineage progression during the critical periods of postnatal myelination has never been explored. Here, we show that acute THC administration at early postnatal ages in mice enhanced OL development and CNS myelination in the subcorti

SUBMITTER: Huerga-Gomez A 

PROVIDER: S-EPMC7821226 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature