Long-term magnesium supplementation improves glucocorticoid metabolism: A post-hoc analysis of an intervention trial.

ABSTRACT:

Objective

Increasing magnesium intake might reduce the risk of cardiovascular disease (CVD). Whether potential effects on cortisol contribute to these beneficial effects on cardiovascular health remains unclear. We therefore studied effects of long-term oral magnesium supplementation on glucocorticoid metabolism, specifically on the excretion of urinary cortisol, cortisone and their metabolites, as well as on the ratios reflecting enzymatic activity of 11β-hydroxysteroid dehydrogenases (11β-HSDs) and A-ring reductases.

Design

A post-hoc analysis of a randomized trial with allocation to a magnesium supplement (350 mg/day) or a placebo for 24-week.

Patients

Forty-nine overweight men and women, aged between 45 and 70 years.

Measurements

Cortisol, cortisone and the

SUBMITTER: Schutten JC 

PROVIDER: S-EPMC7821302 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature