Circadian actions of orexins on the retinorecipient lateral geniculate complex in rat.

ABSTRACT:

Key points

Rhythmic processes in living organisms are controlled by biological clocks. The orexinergic system of the lateral hypothalamus carries circadian information to provide arousal for the brain during the active phase. Here, we show that orexins exert an excitatory action in three parts of the lateral geniculate nucleus (LGN), in particular upon directly retinorecipient neurons in the non-image forming visual structures. We provide evidence for the high nocturnal levels of orexins with stable circadian expression of predominant orexin receptor 2 in the LGN. Our data additionally establish the convergence of orexinergic and pituitary adenylate cyclase (PAC)-activating peptide/PAC1 receptor systems (used by melanopsin-expressing retinal ganglion cells), which directly regulate

SUBMITTER: Chrobok L 

PROVIDER: S-EPMC7821336 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature