Protein liposomes-mediated targeted acetylcholinesterase gene delivery for effective liver cancer therapy.

ABSTRACT:

Background

Effective methods to deliver therapeutic genes to solid tumors and improve their bioavailability are the main challenges of current medical research on gene therapy. The development of efficient non-viral gene vector with tumor-targeting has very important application value in the field of cancer therapy. Proteolipid integrated with tumor-targeting potential of functional protein and excellent gene delivery performance has shown potential for targeted gene therapy.

Results

Herein, we prepared transferrin-modified liposomes (Tf-PL) for the targeted delivery of acetylcholinesterase (AChE) therapeutic gene to liver cancer. We found that the derived Tf-PL/AChE liposomes exhibited much higher transfection efficiency than the commercial product Lipo 2000 and shown premi

SUBMITTER: Wang K 

PROVIDER: S-EPMC7821407 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature