A comprehensive microsatellite landscape of human Y-DNA at kilobase resolution.

ABSTRACT:

Background

Though interest in human simple sequence repeats (SSRs) is increasing, little is known about the exact distributional features of numerous SSRs in human Y-DNA at chromosomal level. Herein, totally 540 maps were established, which could clearly display SSR landscape in every bin of 1 k base pairs (Kbp) along the sequenced part of human reference Y-DNA (NC_000024.10), by our developed differential method for improving the existing method to reveal SSR distributional characteristics in large genomic sequences.

Results

The maps show that SSRs accumulate significantly with forming density peaks in at least 2040 bins of 1 Kbp, which involve different coding, noncoding and intergenic regions of the Y-DNA, and 10 especially high density peaks were reported to associate wi

SUBMITTER: Li D 

PROVIDER: S-EPMC7821415 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature