Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age.

ABSTRACT:

Background

The upper airways present a barrier to inhaled allergens and microbes, which alter immune responses and subsequent risk for diseases, such as allergic rhinitis (AR).

Objective

We tested the hypothesis that early-life microbial exposures leave a lasting signature in DNA methylation that ultimately influences the development of AR in children.

Methods

We studied upper airway microbiota at 1 week, 1 month, and 3 months of life, and measured DNA methylation and gene expression profiles in upper airway mucosal cells and assessed AR at age 6 years in children in the Copenhagen Prospective Studies on Asthma in Childhood birth cohort.

Results

We identified 956 AR-associated differentially methylated CpGs in upper airway mucosal cells at age 6 years, 792 of w

SUBMITTER: Morin A 

PROVIDER: S-EPMC7821422 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature