Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.

ABSTRACT:

Background

Dusp8 is the first GWAS-identified gene that is predominantly expressed in the brain and has previously been linked with the development of diabetes type 2 in humans. In this study, we unravel how Dusp8 is involved in the regulation of sucrose reward behavior.

Methods

Female, chow-fed global Dusp8 WT and KO mice were tested in an observer-independent IntelliCage setup for self-administrative sucrose consumption and preference followed by a progressive ratio task with restricted sucrose access to monitor seeking and motivation behavior. Sixty-three human carriers of the major C and minor T allele of DUSP8 SNP rs2334499 were tested for their perception of food cues by collecting a rating score for sweet versus savory high caloric food.

Results

Dusp8 KO mice s

SUBMITTER: Baumann P 

PROVIDER: S-EPMC7821601 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature