Association of mitochondrial DNA haplogroups J and K with low response in exercise training among Finnish military conscripts.

ABSTRACT:

Background

We have previously suggested that some of the mutations defining mitochondrial DNA (mtDNA) haplogroups J and K produce an uncoupling effect on oxidative phosphorylation and thus are detrimental for elite endurance performance. Here, the association between haplogroups J and K and physical performance was determined in a population-based cohort of 1036 Finnish military conscripts.

Results

Following a standard-dose training period, excellence in endurance performance was less frequent among subjects with haplogroups J or K than among subjects with non-JK haplogroups (p = 0.041), and this finding was more apparent among the best-performing subjects (p < 0.001).

Conclusions

These results suggest that mtDNA haplogroups are one of the genetic determinants explain

SUBMITTER: Kiiskila J 

PROVIDER: S-EPMC7821635 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature