Proinflammatory T cell polarization is already present in patients with early knee osteoarthritis.

ABSTRACT:

Background

Investigating the pathophysiological mechanisms of early osteoarthritis (OA) is of utmost interest since this stage holds the strongest promise for therapeutic interventions. The aims of this study were to analyze if synovial inflammation is already present in early OA and to characterize the involved cell populations, by investigating synovial fluid (SF) and synovial membrane (SM) of early OA patients for the presence and polarization status of CD4 T cells.

Methods

A quantitative analysis of CD4⁺ T cell infiltration in SF and SM compared to peripheral blood (PB) was performed in patients with early stages of OA. We further investigated intracellular staining (ICS), surface marker, and chemokine receptor expression profiles of CD4⁺ T cells in

SUBMITTER: Rosshirt N 

PROVIDER: S-EPMC7821658 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature