Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration.

ABSTRACT: Age-related macular degeneration (AMD), a degenerative disease in the central macula area of the neuroretina and the supporting retinal pigment epithelium, is the most common cause of vision loss in the elderly. Although advances have been made, treatment to prevent the progressive degeneration is lacking. Besides the association of innate immune pathway genes with AMD susceptibility, environmental stress- and cellular senescence-induced alterations in pathways such as metabolic functions and inflammatory responses are also implicated in the pathophysiology of AMD. Cellular senescence is an adaptive cell process in response to noxious stimuli in both mitotic and postmitotic cells, activated by tumor suppressor proteins and prosecuted via an inflammatory secretome. In addition to physiologi

SUBMITTER: Lee KS 

PROVIDER: S-EPMC7821689 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature