Donor oocyte recipients do not benefit from preimplantation genetic testing for aneuploidy to improve pregnancy outcomes.

ABSTRACT:

Study question

Do donor oocyte recipients benefit from preimplantation genetic testing for aneuploidy (PGT-A)?

Summary answer

PGT-A did not improve the likelihood of live birth for recipients of vitrified donor oocytes, but it did avoid embryo transfer in cycles with no euploid embryos.

What is known already

Relative to slow freeze, oocyte vitrification has led to increased live birth from cryopreserved oocytes and has led to widespread use of this technology in donor egg IVF programs. However, oocyte cryopreservation has the potential to disrupt the meiotic spindle leading to abnormal segregation of chromosome during meiosis II and ultimately increased aneuploidy in resultant embryos. Therefore, PGT-A might have benefits in vitrified donor egg cycles. In contrast, em

SUBMITTER: Doyle N 

PROVIDER: S-EPMC7821705 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature