Multiparametric positron emission tomography/magnetic resonance imaging in nasopharyngeal carcinoma: Correlations between magnetic resonance imaging functional parameters and ¹⁸F-fluorodeoxyglucose positron emission tomography imaging biomarkers and their predictive value for treatment failure.

ABSTRACT:

Objectives

The clinical significance of positron emission tomography/magnetic resonance imaging (PET/MRI) functional parameters in nasopharyngealcarcinoma (NPC) remains unclear. The purpose of this prospective study was two-fold: (1) to investigate the associations between simultaneously acquired PET/MRI perfusion, diffusion, and glucose metabolism parameters in patients with NPC and (2) to analyze their predictive value with respect to treatment failure.

Materials and methods

We enrolled 85 patients with primary NPC who simultaneously underwent¹⁸F-fluorodeoxyglucose PET/CT and PET/MRI before definitive treatment. The following variables were determined: (1) functional parameters from the MRI component, including perfusion values (K^trans ,k

SUBMITTER: Chan SC 

PROVIDER: S-EPMC7821831 | biostudies-literature | 2021 Jan-Mar

REPOSITORIES: biostudies-literature