A novel score system of blood tests for differentiating Kawasaki disease from febrile children.

ABSTRACT:

Background

Kawasaki disease is the most common cause of acquired heart disease among febrile children under the age of 5 years old. It is also a clinically diagnosed disease. In this study, we developed and assessed a novel score system using objective parameters to differentiate Kawasaki disease from febrile children.

Methods

We analyzed 6,310 febrile children and 485 Kawasaki disease subjects in this study. We collected biological parameters of a routine blood test, including complete blood count with differential, C-reactive protein, aspartate aminotransferase, and alanine aminotransferase. Receiver operating characteristic curve, logistic regression, and Youden's index were all used to develop the prediction model. Two other independent cohorts from different hospitals w

SUBMITTER: Tsai CM 

PROVIDER: S-EPMC7822339 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature