Pesticide use and incident Parkinson's disease in a cohort of farmers and their spouses.

ABSTRACT:

Background

Extensive literature suggests an association between general pesticide use and Parkinson's disease (PD). However, with few exceptions, little is known about associations between specific pesticides and PD.

Objective

We evaluated use of pesticides and incident PD in 38,274 pesticide applicators and 27,836 of their spouses in the Agricultural Health Study cohort followed over 20 years.

Methods

We used self-reported information on ever-use of 50 specific pesticides as of enrollment for both applicators and spouses, and considered intensity-weighted lifetime days (IWLD) reported at enrollment and through the first 5-year follow-up among applicators. We estimated covariate-adjusted hazard ratios (HR) and 95% confidence intervals (CI) using Cox regression. We als

SUBMITTER: Shrestha S 

PROVIDER: S-EPMC7822498 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature