Human Milk Oligosaccharides and Hispanic Infant Weight Gain in the First 6 Months.

ABSTRACT:

Objective

The aim of this study was to determine whether human milk oligosaccharides (HMOs) at 1 month predicted infant weight gain at 6 months and whether associations varied by HMO secretor status.

Methods

Participants were 157 Hispanic mother-infant pairs. Human milk samples were collected at 1 month. Nineteen individual HMOs were analyzed using high-performance liquid chromatography, and secretor status was determined by the presence of 2'-fucosyllactose or lacto-N-fucopentaose (LNFP) I. Infant weight was measured at 1 and 6 months. Path analysis was used to test effects of HMO composition on infant weight gain, adjusting for maternal age, prepregnancy BMI, and infant age, sex, and birth weight.

Results

In the total sample, higher LNFPII predicted lower infant wei

SUBMITTER: Berger PK 

PROVIDER: S-EPMC7822565 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature