Cocaine addiction severity exacerbates the negative association of lifetime lead exposure with blood pressure levels: Evidence from a pilot study.

ABSTRACT:

Background

High blood pressure (BP) is associated independently with cocaine use and lead exposure. It is not known whether cocaine use and lead exposure act jointly to disrupt cardiovascular health.

Objective

To determine whether cocaine use modifies the association between cumulative lead levels and elevated BP.

Materials and methods

We measured cumulative tibia lead levels in 35 adults: 20 with cocaine use disorder (CUD) and 15 non-CUD controls using in vivo K-shell X-ray fluorescence. Generalized estimating equation regression determined associations between log₂-transformed lead and BP (systolic, diastolic, and mean arterial pressure) and assessed the modifying association of cocaine use (as addiction severity) on the lead-BP relationship, adjus

SUBMITTER: Colicino E 

PROVIDER: S-EPMC7822570 | biostudies-literature | 2019 Jul-Sep

REPOSITORIES: biostudies-literature