Comprehensive Analysis of ceRNA Regulation Network Involved in the Development of Coronary Artery Disease.

ABSTRACT:

Background

Coronary artery disease (CAD) is one of the most common causes of sudden death with high morbidity in recent years. This paper is aimed at exploring the early peripheral blood biomarkers of sudden death and providing a new perspective for clinical diagnosis and forensic pathology identification by integrated bioinformatics analysis.

Methods

Two microarray expression profiling datasets (GSE113079 and GSE31568) were downloaded from the Gene Expression Omnibus (GEO) database, and we identified differentially expressed lncRNAs, miRNAs, and mRNAs in CAD. Gene Ontology (GO) and KEGG pathway analyses of DEmRNAs were executed. A protein-protein interaction (PPI) network was constructed, and hub genes were identified. Finally, we constructed a competitive endogenous RNA (c

SUBMITTER: He J 

PROVIDER: S-EPMC7822659 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature