Proteomic Profiling Reveals the Molecular Changes of Insomnia Patients.

ABSTRACT:

Background

Insomnia is an economic burden and public health problem. This study is aimed at exploring potential biological pathways and protein networks for insomnia characterized by wakefulness after sleep.

Method

Proteomics analysis was performed in the insomnia group with wakefulness and the control group. The differentially expressed proteins (DEPs) were enriched; then, hub proteins were identified by protein-protein interaction (PPI) network and verified by parallel reaction monitoring (PRM).

Results

Compared with the control group, the sleep time and efficiency of insomnia patients were decreased, and awakening time and numbers after sleep onset were significantly increased (P < 0.001). The results of proteomic sequencing found 68 DEPs in serum under 1.2-

SUBMITTER: Wang G 

PROVIDER: S-EPMC7822674 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature