Melatonin Alters Fluid Phase Coexistence in POPC/DPPC/Cholesterol Membranes.

ABSTRACT: The structure and biophysical properties of lipid membranes are important for cellular functions in health and disease. In Alzheimer's disease, the neuronal membrane is a target for toxic amyloid-β (Aβ). Melatonin is an important pineal gland hormone that has been shown to protect against Aβ toxicity in cellular and animal studies, but the molecular mechanism of this protection is not fully understood. Melatonin is a small membrane-active molecule that has been shown to interact with model lipid membranes and alter the membrane biophysical properties, such as membrane molecular order and dynamics. This effect of melatonin has been previously studied in simple model bilayers with one or two lipid components. To make it more relevant to neuronal membranes, we used a more complex ternary lipi

SUBMITTER: Mei N 

PROVIDER: S-EPMC7822731 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature