Genome-wide analysis of DNA G-quadruplex motifs across 37 species provides insights into G4 evolution.

ABSTRACT: G-quadruplex (G4) structures have been predicted in the genomes of many organisms and proven to play regulatory roles in diverse cellular activities. However, there is little information on the evolutionary history and distribution characteristics of G4s. Here, whole-genome characteristics of potential G4s were studied in 37 evolutionarily representative species. During evolution, the number, length, and density of G4s generally increased. Immunofluorescence in seven species confirmed G4s' presence and evolutionary pattern. G4s tended to cluster in chromosomes and were enriched in genetic regions. Short-loop G4s were conserved in most species, while loop-length diversity also existed, especially in mammals. The proportion of G4-bearing genes and orthologue genes, which appeared to be incre

SUBMITTER: Wu F 

PROVIDER: S-EPMC7822830 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature