Impact of the repurposed drug thonzonium bromide on host oral-gut microbiomes.

ABSTRACT: Drug repurposing is a feasible strategy for the development of novel therapeutic applications. However, its potential use for oral treatments and impact on host microbiota remain underexplored. Here, we assessed the influences of topical oral applications of a repurposed FDA-approved drug, thonzonium bromide, on gastrointestinal microbiomes and host tissues in a rat model of dental caries designed to reduce cross-contamination associated with coprophagy. Using this model, we recapitulated the body site microbiota that mirrored the human microbiome profile. Oral microbiota was perturbed by the treatments with specific disruption of Rothia and Veillonella without affecting the global composition of the fecal microbiome. However, disturbances in the oral-gut microbial interactions were identi

SUBMITTER: Simon-Soro A 

PROVIDER: S-EPMC7822857 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature