Utility of T₂-weighted MRI texture analysis in assessment of peripheral zone prostate cancer aggressiveness: a single-arm, multicenter study.

ABSTRACT: T₂-weighted (T₂W) MRI provides high spatial resolution and tissue-specific contrast, but it is predominantly used for qualitative evaluation of prostate anatomy and anomalies. This retrospective multicenter study evaluated the potential of T₂W image-derived textural features for quantitative assessment of peripheral zone prostate cancer (PCa) aggressiveness. A standardized preoperative multiparametric MRI was performed on 87 PCa patients across 6 institutions. T₂W intensity and apparent diffusion coefficient (ADC) histogram, and T₂W textural features were computed from tumor volumes annotated based on whole-mount histology. Spearman correlations were used to evaluate association between textural features and PCa grade groups (i.e. 1-5)

SUBMITTER: Nketiah GA 

PROVIDER: S-EPMC7822867 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature