Perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders.

ABSTRACT: This study employed a series of heartbeat perception tasks to assess the hypothesis that cardiac interoceptive processing in individuals with depression/anxiety (N = 221), and substance use disorders (N = 136) is less flexible than that of healthy individuals (N = 53) in the context of physiological perturbation. Cardiac interoception was assessed via heartbeat tapping when: (1) guessing was allowed; (2) guessing was not allowed; and (3) experiencing an interoceptive perturbation (inspiratory breath hold) expected to amplify cardiac sensation. Healthy participants showed performance improvements across the three conditions, whereas those with depression/anxiety and/or substance use disorder showed minimal improvement. Machine learning analyses suggested that individual differences in these

SUBMITTER: Smith R 

PROVIDER: S-EPMC7822872 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature