Genetic deletion of Abcc6 disturbs cholesterol homeostasis in mice.

ABSTRACT: Genetic studies link adenosine triphosphate-binding cassette transporter C6 (ABCC6) mutations to pseudoxanthoma elasticum (PXE). ABCC6 sequence variations are correlated with altered HDL cholesterol levels and an elevated risk of coronary artery diseases. However, the role of ABCC6 in cholesterol homeostasis is not widely known. Here, we report reduced serum cholesterol and phytosterol levels in Abcc6-deficient mice, indicating an impaired sterol absorption. Ratios of cholesterol precursors to cholesterol were increased, confirmed by upregulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase (Hmgcr) expression, suggesting activation of cholesterol biosynthesis in Abcc6^-/- mice. We found that cholesterol depletion was accompanied by a substantial decrease in HDL chol

SUBMITTER: Ibold B 

PROVIDER: S-EPMC7822913 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature