Dlx5-augmentation in neural crest cells reveals early development and differentiation potential of mouse apical head mesenchyme.

ABSTRACT: Neural crest cells (NCCs) give rise to various tissues including neurons, pigment cells, bone and cartilage in the head. Distal-less homeobox 5 (Dlx5) is involved in both jaw patterning and differentiation of NCC-derivatives. In this study, we investigated the differentiation potential of head mesenchyme by forcing Dlx5 to be expressed in mouse NCC (NCC^Dlx5). In NCC^Dlx5 mice, differentiation of dermis and pigment cells were enhanced with ectopic cartilage (ec) and heterotopic bone (hb) in different layers at the cranial vertex. The ec and hb were derived from the early migrating mesenchyme (EMM), the non-skeletogenic cell population located above skeletogenic supraorbital mesenchyme (SOM). The ec developed within Foxc1⁺-dura mater with increased PDGFRα sign

SUBMITTER: Vu TH 

PROVIDER: S-EPMC7822927 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature