Ontology highlight
ABSTRACT:
SUBMITTER: Alqassim EY
PROVIDER: S-EPMC7822933 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Communications biology 20210122 1
Pro-inflammatory M1 macrophage polarization is associated with microbicidal and antitumor responses. We recently described APOBEC3A-mediated cytosine-to-uracil (C > U) RNA editing during M1 polarization. However, the functional significance of this editing is unknown. Here we find that APOBEC3A-mediated cellular RNA editing can also be induced by influenza or Maraba virus infections in normal human macrophages, and by interferons in tumor-associated macrophages. Gene knockdown and RNA_Seq analys ...[more]