Impact of Intermediate Hyperglycemia and Diabetes on Immune Dysfunction in Tuberculosis.

ABSTRACT:

Background

People with diabetes have an increased risk of developing active tuberculosis (TB) and are more likely to have poor TB-treatment outcomes, which may impact on control of TB as the prevalence of diabetes is increasing worldwide. Blood transcriptomes are altered in patients with active TB relative to healthy individuals. The effects of diabetes and intermediate hyperglycemia (IH) on this transcriptomic signature were investigated to enhance understanding of immunological susceptibility in diabetes-TB comorbidity.

Methods

Whole blood samples were collected from active TB patients with diabetes (glycated hemoglobin [HbA1c] ≥6.5%) or IH (HbA1c = 5.7% to <6.5%), TB-only patients, and healthy controls in 4 countries: South Africa, Romania, Indonesia, and Peru. Differenti

SUBMITTER: Eckold C 

PROVIDER: S-EPMC7823074 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature