The secretome of stressed peripheral blood mononuclear cells increases tissue survival in a rodent epigastric flap model.

ABSTRACT: Reconstructive surgery transfers viable tissue to cover defects and to restore aesthetic and functional properties. Failure rates after free flap surgery range from 3 to 7%. Co-morbidities such as diabetes mellitus or peripheral vascular disease increase the risk of flap failure up to 4.5-fold. Experimental therapeutic concepts commonly use a monocausal approach by applying single growth factors. The secretome of γ-irradiated, stressed peripheral blood mononuclear cells (PBMCsec) resembles the physiological environment necessary for tissue regeneration. Its application led to improved wound healing rates and a two-fold increase in blood vessel counts in previous animal models. We hypothesized that PBMCsec has beneficial effects on the survival of compromised flap tissue by reducing the nec

SUBMITTER: Hacker S 

PROVIDER: S-EPMC7823127 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature